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This is augmented by the infiltration of macrophages and activation of the innate immune cells [26], which triggers hyperinsulinemia that inhibits lipolysis and activates lipoprotein lipase (LPL)

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In summary, VNS technology holds promise to break through the limitations of traditional PD treatments through mechanism-driven targeted interventions and clinically adaptable technological empowerment, ultimately achieving a paradigm shift from symptom control to disease modification. Statements Author contributions LY: Writing review & editing, Writing original draft